@article{TEXTUAL,
      recid = {8554},
      author = {Urbanek, Margrit and Hayes, M. Geoffrey and Lee, Hoon and  Freathy, Rachel M. and Lowe, Lynn P. and Ackerman,  Christine and Jafari, Nadereh and Dyer, Alan R. and Cox,  Nancy J. and Dunger, David B. and Hattersley, Andrew T. and  Metzger, Boyd E. and Lowe Jr., William L.},
      title = {The Role of Inflammatory Pathway Genetic Variation on  Maternal Metabolic Phenotypes during Pregnancy},
      journal = {PLOS ONE},
      address = {2012-03-30},
      number = {TEXTUAL},
      abstract = {&lt;p&gt;Background: Since mediators of inflammation are  associated with insulin resistance, and the risk of  developing diabetes mellitus and gestational diabetes, we  hypothesized that genetic variation in members of the  inflammatory gene pathway impact glucose levels and related  phenotypes in pregnancy. We evaluated this hypothesis by  testing for association between genetic variants in 31  inflammatory pathway genes in the Hyperglycemia and Adverse  Pregnancy Outcome (HAPO) cohort, a large multiethnic  multicenter study designed to address the impact of  glycemia less than overt diabetes on pregnancy  outcome.&lt;/p&gt;&lt;p&gt;Results: Fasting, 1-hour, and 2-hour  glucose, fasting and 1-hour C-peptide, and HbA1c levels  were measured in blood samples obtained from HAPO  participants during an oral glucose tolerance test at 24-32  weeks gestation. We tested for association between 458 SNPs  mapping to 31 genes in the inflammatory pathway and  metabolic phenotypes in 3836 European ancestry and 1713  Thai pregnant women. The strongest evidence for association  was observed with &lt;em&gt;TNF alpha&lt;/em&gt; and HbA1c (rs1052248;  0.04% increase per allele C;  p-value = 4.4×10&lt;sup&gt;−5&lt;/sup&gt;), &lt;em&gt;RETN&lt;/em&gt; and fasting  plasma glucose (rs1423096; 0.7 mg/dl decrease per allele A;  p-value = 1.1×10&lt;sup&gt;−4&lt;/sup&gt;), &lt;em&gt;IL8&lt;/em&gt; and 1 hr  plasma glucose (rs2886920; 2.6 mg/dl decrease per allele T;  p-value = 1.3×10&lt;sup&gt;−4&lt;/sup&gt;), &lt;em&gt;ADIPOR2&lt;/em&gt; and  fasting C-peptide (rs2041139; 0.55 ug/L decrease per allele  A; p-value = 1.4×10&lt;sup&gt;−4&lt;/sup&gt;), &lt;em&gt;LEPR&lt;/em&gt; and 1-hour  C-peptide (rs1171278; 0.62 ug/L decrease per allele T;  p-value = 2.4×10&lt;sup&gt;−4&lt;/sup&gt;), and &lt;em&gt;IL6&lt;/em&gt; and 1-hour  plasma glucose (rs6954897; −2.29 mg/dl decrease per allele  G, p-value = 4.3×10&lt;sup&gt;−4&lt;/sup&gt;).&lt;/p&gt;&lt;p&gt;Conclusion: Based  on the genes surveyed in this study the inflammatory  pathway is unlikely to have a strong impact on maternal  metabolic phenotypes in pregnancy although variation in  individual members of the pathway (e.g. &lt;em&gt;RETN&lt;/em&gt;,  &lt;em&gt;IL8&lt;/em&gt;, &lt;em&gt;ADIPOR2&lt;/em&gt;, &lt;em&gt;LEPR&lt;/em&gt;,  &lt;em&gt;IL6&lt;/em&gt;, and &lt;em&gt;TNF alpha&lt;/em&gt;,) may contribute to  metabolic phenotypes in pregnant women.&lt;/p&gt;},
      url = {http://knowledge.uchicago.edu/record/8554},
}