@article{PATENT, recid = {8480}, title = {CONVERSION OF CARDIOMYOCYTES INTO FAST CONDUCTING CARDIOMYOCYTES OR SLOW CONDUCTING NODAL CELLS}, number = {PATENT}, month = {Jun}, year = {2015}, abstract = {Tbx5 and Tbx3 were shown to be key determinants of regional identity in the AVCS. Various embodiments relate to increasing the amount of Tbx5 or Tbx3 in a cardiomyoctye whereby the cardiomycyte is converted to a fast conducting cardiomyocyte or a slow conducting nodal cell, respectively. Further embodiments employ the fast conducting cardiomyocytes and nodal cells in therapeutic methods and in methods for screening compounds for effect on these cell types.}, url = {http://knowledge.uchicago.edu/record/8480}, }