000008459 001__ 8459
000008459 005__ 20240725122357.0
000008459 024__ $$aUS 201314061331 A
000008459 024__ $$dUS 2014/0142133 A1
000008459 037__ $$aPATENT
000008459 041__ $$aEnglish
000008459 245__ $$aMODULATION OF CELL BARRIER DYSFUNCTION
000008459 260__ $$c2014-05-22
000008459 260__ $$g2013-10-23
000008459 336__ $$aPatent
000008459 520__ $$aThe invention provides prophylactic and therapeutic methods for administering a μ-opioid receptor antagonist, e.g., N-methylnaltrexone or a salt thereof, to treat cell barrier diseases and disorders, such as endothelial and epithelial cell barrier diseases and disorders, e.g., sepsis. Methods of reducing at least a symptom of sepsis and the risk of developing sepsis are also provided.
000008459 690__ $$aBiological Sciences Division
000008459 691__ $$aSurgery
000008459 691__ $$aAnesthesia and Critical Care
000008459 7011_ $$aAlverdy, John C.$$uUniversity of Chicago
000008459 7011_ $$aMoss, Jonathan$$uUniversity of Chicago
000008459 7011_ $$aLingen, Mark W.$$uUniversity of Chicago
000008459 7011_ $$aSingleton, Patrick A.$$uUniversity of Chicago
000008459 7011_ $$aGarcia, Joe G. N.$$uUniversity of Chicago
000008459 7121_ $$aUniversity of Chicago
000008459 7131_ $$aUniversity of Chicago
000008459 8564_ $$9fc5adb03-e345-4f0a-8f6a-64e2dc278e23$$ePublic$$s4024467$$uhttps://knowledge.uchicago.edu/record/8459/files/US20140142133.pdf
000008459 909CO $$ooai:uchicago.tind.io:8459$$pGLOBAL_SET
000008459 983__ $$aPatent