@article{TEXTUAL,
      recid = {8447},
      author = {Bavi, Navid and Cox, Charles D. and Nikolaev, Yury A. and  Martinac, Boris},
      title = {Molecular insights into the force-from-lipids gating of  mechanosensitive channels},
      journal = {Current Opinion in Physiology},
      address = {2023-08-21},
      number = {TEXTUAL},
      abstract = {It is well-established that mechanosensitive (MS) ion  channels differentially respond to membrane tension,  bilayer thinning, and curvature. The thesis that the lipid  bilayer acted as the terminal transducer of force directly  to the channel became known as the force-from-lipids gating  paradigm (also less frequently referred to as the ‘bilayer  model’). This principle allows cells to detect and respond  to mechanical forces in their environment, which is  important for various physiological processes, including  blood pressure regulation, touch sensation, and many  others. Our understanding of how mechanical force drives MS  channel gating has been greatly enhanced by new insights  into the molecular interactions between the lipid bilayer  and channel proteins. In this short review, we revisit the  role of the force-from-lipids principle within the current  understanding of MS channel gating and focus on its  molecular underpinnings.},
      url = {http://knowledge.uchicago.edu/record/8447},
}