000008435 001__ 8435
000008435 005__ 20250218124627.0
000008435 02470 $$ahttps://doi.org/10.1371/journal.pone.0015475$$2doi
000008435 037__ $$aTEXTUAL
000008435 037__ $$bArticle
000008435 041__ $$aeng
000008435 245__ $$aCue-Reactors: Individual Differences in Cue-Induced Craving after Food or Smoking Abstinence
000008435 269__ $$a2010-11-10
000008435 336__ $$aArticle
000008435 520__ $$a&lt;p&gt;Background: Pavlovian conditioning plays a critical role in both drug addiction and binge eating. Recent animal research suggests that certain individuals are highly sensitive to conditioned cues, whether they signal food or drugs. Are certain humans also more reactive to both food and drug cues?&lt;/p&gt;&lt;p&gt;Methods: We examined cue-induced craving for both cigarettes and food, in the same individuals (n = 15 adult smokers). Subjects viewed smoking-related or food-related images after abstaining from either smoking or eating.&lt;/p&gt;&lt;p&gt;Results: Certain individuals reported strong cue-induced craving after both smoking and food cues. That is, subjects who reported strong cue-induced craving for cigarettes also rated stronger cue-induced food craving.&lt;/p&gt;&lt;p&gt;Conclusions: In humans, like in nonhumans, there may be a “cue-reactive” phenotype, consisting of individuals who are highly sensitive to conditioned stimuli. This finding extends recent reports from nonhuman studies. Further understanding this subgroup of smokers may allow clinicians to individually tailor therapies for smoking cessation.&lt;/p&gt;
000008435 536__ $$oNIDA$$cR01 DA002812
000008435 540__ $$a&lt;p&gt;© 2010 Mahler, de Wit. &lt;/p&gt; &lt;p&gt;This is an open access article distributed under the terms of the &lt;a href="http://creativecommons.org/licenses/by/4.0/" target="_blank"&gt;Creative Commons Attribution License&lt;/a&gt;, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.&lt;/p&gt;
000008435 542__ $$fCC BY
000008435 690__ $$aBiological Sciences Division
000008435 691__ $$aPsychiatry and Behavioral Neuroscience
000008435 7001_ $$aMahler, Stephen V.$$uMedical University of South Carolina
000008435 7001_ $$ade Wit, Harriet$$uUniversity of Chicago
000008435 773__ $$tPLOS ONE
000008435 8564_ $$yArticle$$907ce5f21-ae45-4f02-9118-152b68d4e330$$s158711$$uhttps://knowledge.uchicago.edu/record/8435/files/journal.pone.0015475.pdf$$ePublic
000008435 909CO $$ooai:uchicago.tind.io:8435$$pGLOBAL_SET
000008435 983__ $$aArticle