@article{TEXTUAL,
      recid = {8399},
      author = {White, Steven R. and Floreth, Timothy and Liao, Chuanhong  and Bhorade, Sangeeta M.},
      title = {Association of Soluble HLA-G with Acute Rejection Episodes  and Early Development of Bronchiolitis Obliterans in Lung  Transplantation},
      journal = {PLOS ONE},
      address = {2014-07-28},
      number = {TEXTUAL},
      abstract = {<p>Lung transplantation has evolved into a life-saving  therapy for select patients with end-stage lung diseases.  However, long-term survival remains limited because of  bronchiolitis obliterans syndrome (BOS). Soluble HLA-G, a  mediator of adaptive immunity that modulates regulatory T  cells and certain classes of effector T cells, may be a  useful marker of survival free of BOS. We conducted a  retrospective, single-center, pilot review of 38 lung  transplant recipients who underwent collection of serum and  bronchoalveolar lavage fluid 3, 6 and 12 months after  transplantation, and compared soluble HLA-G concentrations  in each to the presence of type A rejection and lymphocytic  bronchiolitis in the first 12 months and to the presence of  BOS at 24 months after transplantation. Lung soluble HLA-G  concentrations were directly related to the presence of  type A rejection but not to lymphocytic bronchiolitis. Our  data demonstrate that soluble HLA-G concentrations in  bronchoalveolar lavage but not in serum correlates with the  number of acute rejection episodes in the first 12 months  after lung transplantation, and thus may be a reactive  marker of rejection.</p>},
      url = {http://knowledge.uchicago.edu/record/8399},
}