@article{PATENT, recid = {8329}, title = {Methods and composition involving thermophilic fibronectin type III (FN3) monobodies}, number = {PATENT}, month = {Jun}, year = {2023}, abstract = {The current application describes various compositions and methods for the production of FN3-based binding proteins with improved stability properties. Aspects of the disclosure relate to polypeptides comprising a variant fibronectin type III (FN3) domain from Sulfolobus tokodaii or Pyrococcus horikoshii comprising one or more amino acid substitutions or insertions in a loop region of FN3, in a non-loop region of FN3, or in both. }, url = {http://knowledge.uchicago.edu/record/8329}, }