@article{PATENT, recid = {8031}, title = {HIGHLY DIASTEREOSELECTIVE CONSTRUCTION OF THE 4,5-SPIROCYCLE VIA PALLADIUM-CATALYZED INTRAMOLECULAR ALKENYLATION}, number = {PATENT}, month = {Mar}, year = {2020}, abstract = {A diastereoselective method of preparing benzofuran-based 4,5-spirocycles via metal catalyzed alkenylation is described. The method can be used to provide compounds containing the benzofuranone-4,5-spirocyclic motif of the phainanoids, a class a natural products having immunosuppressive activity. Synthetic analogs of phainanoids, e.g., compounds that mimic the structure of the “western” part of the structure of the phainanoids and that contain the benzofuranone-4,5-spirocycle are described, as well as their synthetic intermediates, and their methods of synthesis.}, url = {http://knowledge.uchicago.edu/record/8031}, }