@article{PATENT,
      recid = {7906},
      title = {SYNTHETIC SUBSTRATES FOR ENZYMES THAT CATALYZE REACTIONS  OF MODIFIED CYSTEINES AND RELATED METHODS},
      number = {PATENT},
      month = {May},
      year = {2018},
      abstract = {Synthetic probes for detecting the activity of enzymes  that catalyze reactions of post-translationally modified  cysteine residues are described. The probes include  “turn-on” probes that include a carbamate linkage that  is cleaved via an intramolecular reaction with a free thiol  produced by an enzyme catalyzed activity. The probes also  include ratiometric, Michael addition-based probes that  respond to enzymatic activity by a change in structure that  results in a change in fluorescence properties. Methods of  using the probes to detect enzymatic activity and disease  are described. For example, the probes can be used to  detect enzymatic activity in a variety of samples,  including live cells and heterogeneous tissues. In  addition, prodrugs that can be activated by enzymes that  catalyze reactions of post-translationally modified  cysteine residues and methods of using the prodrugs to  treat disease are described.},
      url = {http://knowledge.uchicago.edu/record/7906},
}