000007409 001__ 7409 000007409 005__ 20240523050958.0 000007409 024__ $$aUS 11059866 B2 000007409 024__ $$dUS 201916661155 A 000007409 037__ $$aPATENT 000007409 041__ $$aEnglish 000007409 245__ $$aCompositions and methods related to protein A (SpA) variants 000007409 260__ $$c2021-07-13 000007409 260__ $$g2019-10-23 000007409 336__ $$aPatent 000007409 520__ $$aThe present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve a non-toxigenic Protein A (SpA) variant. 000007409 690__ $$aBiological Sciences Division 000007409 691__ $$aMicrobiology 000007409 7011_ $$aSchneewind, Olaf$$uUniversity of Chicago 000007409 7011_ $$aCheng, Alice G.$$uUniversity of Chicago 000007409 7011_ $$aMissiakas, Dominique M.$$uUniversity of Chicago 000007409 7011_ $$aKim, Hwan Keun$$uUniversity of Chicago 000007409 7121_ $$aUniversity of Chicago 000007409 7131_ $$aUniversity of Chicago 000007409 8564_ $$9d8bacbfd-ca71-4cfe-b2bf-742b2ce711ef$$s5212761$$uhttps://knowledge.uchicago.edu/record/7409/files/US11059866.pdf$$ePublic 000007409 909CO $$ooai:uchicago.tind.io:7409$$pGLOBAL_SET 000007409 983__ $$aPatent