@article{TEXTUAL,
      recid = {7224},
      author = {Wool, Geoffrey D. and Carll, Timothy},
      title = {Viscoelastic testing: Critical appraisal of new  methodologies and current literature},
      journal = {International Journal of Laboratory Hematology},
      address = {2023-08-09},
      number = {TEXTUAL},
      abstract = {United States Food and Drug Administration (FDA)-approved  viscoelastic testing (VET) methodologies have significantly  changed in the last 10 years, with the availability of  cartridge-based VET. Some of these cartridge-based  methodologies use harmonic resonance-based clot detection.  While VET has always allowed for the evaluation of  real-time clot formation, cartridge-based VET provides  increased ease of use as well as greater portability and  robustness of results in out-of-laboratory environments.  Here we review the use of VET in a variety of clinical  contexts, including cardiac surgery, trauma, liver  transplant, obstetrics, and hypercoagulable states such as  COVID-19. As of now, high quality randomized trial evidence  for new generation VET (TEG 6s, HemoSonics Quantra, ROTEM  sigma) is limited. Nevertheless, the use of VET-guided  transfusion algorithms appears to result in reduced blood  usage without worsening of patient outcomes. Future work  comparing the new generation VET instruments and continuing  to validate clinically important cut-offs will help move  the field of point-of-care coagulation monitoring forward  and increase the quality of transfusion management in  bleeding patients.},
      url = {http://knowledge.uchicago.edu/record/7224},
}