@article{TEXTUAL,
      recid = {6667},
      author = {Dayob, Kenana and Zengin, Aygul and Garifullin, Ruslan and  Guler, Mustafa O. and Abdullin, Timur I. and Yergeshov,  Abdulla and Salakhieva, Diana V. and Cong, Hong Hanh and  Zoughaib, Mohamed},
      title = {Metal-Chelating Self-Assembling Peptide Nanofiber  Scaffolds for Modulation of Neuronal Cell Behavior},
      journal = {Micromachines},
      address = {2023-04-19},
      number = {TEXTUAL},
      abstract = {Synthetic peptides are promising structural and functional  components of bioactive and tissue-engineering scaffolds.  Here, we demonstrate the design of self-assembling  nanofiber scaffolds based on peptide amphiphile (PA)  molecules containing multi-functional histidine residues  with trace metal (TM) coordination ability. The  self-assembly of PAs and characteristics of PA nanofiber  scaffolds along with their interaction with Zn, Cu, and Mn  essential microelements were studied. The effects of  TM-activated PA scaffolds on mammalian cell behavior,  reactive oxygen species (ROS), and glutathione levels were  shown. The study reveals the ability of these scaffolds to  modulate adhesion, proliferation, and morphological  differentiation of neuronal PC-12 cells, suggesting a  particular role of Mn(II) in cell-matrix interaction and  neuritogenesis. The results provide a proof-of-concept for  the development of histidine-functionalized peptide  nanofiber scaffolds activated with ROS- and cell-modulating  TMs to induce regenerative responses.},
      url = {http://knowledge.uchicago.edu/record/6667},
}