@article{TEXTUAL,
      recid = {6652},
      author = {Zhang, Song and Xiao, Qianyi and Shi, Zhuqing and Yu,  Guopeng and Ma, Xiao-Pin and Chen, Haitao and Zhang,  Pengyin and Shen, Suqin and Sai-Yin, He-Xi and Chen,  Tao-Yang and Lu, Pei-Xin and Wang, Neng-Jin and Ren, Weihua  and Huang, Peng and Xie, Jun and Conran, Carly and Zheng,  S. Lilly and Yu, Long and Xu, Jianfeng and Jiang, De-Ke},
      title = {Caspase polymorphisms and prognosis of hepatocellular  carcinoma},
      journal = {PLOS ONE},
      address = {2017-04-28},
      number = {TEXTUAL},
      abstract = {The aim of our study was to determine the impact of  genetic polymorphisms in the caspase (CASP) genes on  prognosis of hepatocellular carcinoma (HCC). We genotyped 7  potentially functional polymorphisms in CASP3, CASP7,  CASP8, CASP9, CASP10 genes in 362 HCC patients of receiving  surgical resection of HCC tumor. The associations of  genotype and haplotype with overall survival (OS) and  disease free survival (DFS) were analyzed by using the Cox  proportional hazards model. We found that the CASP9  rs4645981 C allele was significantly associated with  positive effect on DFS (P = 0.011 and 0.016 for CT+CC vs.  TT in univariate and multivariate analysis, respectively),  CT genotype was associated with a better OS of HCC than the  TT genotype both in univariate and multivariate analysis (P  = 0.048 and 0.041, respectively). Moreover, the CASP3  rs2705897 GT genotype showed marginally significant  association with decreased OS and DFS, compared with the GG  genotype. One haplotype TT/TG in CASP3 (constructed by  rs12108497 T>C and rs2705897 T>G) was significantly  associated with decreased OS and DFS, compared to the  common haplotype TT/TT both in univariate analysis (P =  0.021 and 0.026, respectively) and multivariate analysis (P  = 0.025 and 0.030, respectively). The haplotype GT/GT in  CASP9 (constructed by rs4645978 A>G and rs4645981 C>T) was  significantly associated with decreased DFS both in  univariate and multivariate analysis (P = 0.012 and 0.010,  respectively). In conclusion, the CASP9 rs4645981  polymorphism, CASP3 and CASP9 haplotypes may be useful  prognosis markers for HCC patients with surgical resection  of tumor.},
      url = {http://knowledge.uchicago.edu/record/6652},
}