TY  - GEN
AB  - <p>Background: It is critical to understand the mechanisms of human cancers in order to develop the effective anti-cancer therapeutic strategies. Recent studies indicated that primase polymerase (PRIMPOL) is strongly associated with the development of human cancers. Nevertheless, a systematic pan-cancer analysis of PRIMPOL remains to be further clarified.</p> <p>Method: Comprehensive multi-omics bioinformatics algorithms, such as TIMER2.0, GEPIA2.0 and cBioPortal, were utilized to evaluate the biological roles of PRIMPOL in pan-cancer, including the expression profiles, genomic alterations, prognostic values and immune regulation.</p> <p>Results: PRIMPOL was upregulated in glioblastoma multiforme and kidney renal clear cell carcinoma. The brain lower grade glioma patients with enhanced PRIMPOL expression displayed poor prognostic values. We also demonstrated the PRIMPOL's immunomodulating effects on pan-cancer as well as its genomic changes and methylation levels. The aberrant expression of PRIMPOL was linked to various cancer-associated pathways, including DNA damage response, DNA repair, and angiogenesis, according to single-cell sequencing and function enrichment.</p> <p>Conclusions: This pan-cancer analysis offers a thorough review of the functional roles of PRIMPOL in human cancers, suggesting PRIMPOL as a potentially important biomarker for the progression and immunotherapy of various cancers.</p>
AD  - The Third Xiangya Hospital
AD  - University of Chicago
AD  - Xiangya Hospital
AD  - The Third Xiangya Hospital
AD  - Xiangya Changde Hospital
AU  - Deng, Langmei
AU  - Thakur, Abhimanyu
AU  - Peng, Jinwu
AU  - Song, Liying
AU  - Li, Zhilan
DA  - 2023-06-30
ID  - 6649
JF  - European Journal of Medical Research
KW  - Cancer
KW  - DNA damage response
KW  - Immune infiltration
KW  - PRIMPOL
KW  - Prognosis
L1  - https://knowledge.uchicago.edu/record/6649/files/Multi-omics-analysis-of-DNA-replication-associated-primase-polymerase-PRIMPOL-in-pan-cancer.pdf
L1  - https://knowledge.uchicago.edu/record/6649/files/Supplementary-information.zip
L2  - https://knowledge.uchicago.edu/record/6649/files/Multi-omics-analysis-of-DNA-replication-associated-primase-polymerase-PRIMPOL-in-pan-cancer.pdf
L2  - https://knowledge.uchicago.edu/record/6649/files/Supplementary-information.zip
L4  - https://knowledge.uchicago.edu/record/6649/files/Multi-omics-analysis-of-DNA-replication-associated-primase-polymerase-PRIMPOL-in-pan-cancer.pdf
L4  - https://knowledge.uchicago.edu/record/6649/files/Supplementary-information.zip
LA  - eng
LK  - https://knowledge.uchicago.edu/record/6649/files/Multi-omics-analysis-of-DNA-replication-associated-primase-polymerase-PRIMPOL-in-pan-cancer.pdf
LK  - https://knowledge.uchicago.edu/record/6649/files/Supplementary-information.zip
N2  - <p>Background: It is critical to understand the mechanisms of human cancers in order to develop the effective anti-cancer therapeutic strategies. Recent studies indicated that primase polymerase (PRIMPOL) is strongly associated with the development of human cancers. Nevertheless, a systematic pan-cancer analysis of PRIMPOL remains to be further clarified.</p> <p>Method: Comprehensive multi-omics bioinformatics algorithms, such as TIMER2.0, GEPIA2.0 and cBioPortal, were utilized to evaluate the biological roles of PRIMPOL in pan-cancer, including the expression profiles, genomic alterations, prognostic values and immune regulation.</p> <p>Results: PRIMPOL was upregulated in glioblastoma multiforme and kidney renal clear cell carcinoma. The brain lower grade glioma patients with enhanced PRIMPOL expression displayed poor prognostic values. We also demonstrated the PRIMPOL's immunomodulating effects on pan-cancer as well as its genomic changes and methylation levels. The aberrant expression of PRIMPOL was linked to various cancer-associated pathways, including DNA damage response, DNA repair, and angiogenesis, according to single-cell sequencing and function enrichment.</p> <p>Conclusions: This pan-cancer analysis offers a thorough review of the functional roles of PRIMPOL in human cancers, suggesting PRIMPOL as a potentially important biomarker for the progression and immunotherapy of various cancers.</p>
PY  - 2023-06-30
T1  - Multi-omics analysis of DNA replication-associated primase polymerase (PRIMPOL) in pan-cancer: A potential target for prognosis and immune response
TI  - Multi-omics analysis of DNA replication-associated primase polymerase (PRIMPOL) in pan-cancer: A potential target for prognosis and immune response
UR  - https://knowledge.uchicago.edu/record/6649/files/Multi-omics-analysis-of-DNA-replication-associated-primase-polymerase-PRIMPOL-in-pan-cancer.pdf
UR  - https://knowledge.uchicago.edu/record/6649/files/Supplementary-information.zip
Y1  - 2023-06-30
ER  -