@article{TEXTUAL,
      recid = {6622},
      author = {Roche, Kimberly E. and Bjork, Johannes R. and Dasari,  Mauna R. and Grieneisen, Laura and Jansen, David and Gould,  Trevor J. and Gesquiere, Laurence R. and Barreiro, Luis B.  and Alberts, Susan C. and Blekhman, Ran and Gilbert, Jack  A. and Tung, Jenny and Mukherjee, Sayan and Archie,  Elizabeth A.},
      title = {Universal gut microbial relationships in the gut  microbiome of wild baboons},
      journal = {eLife},
      address = {2023-05-09},
      number = {TEXTUAL},
      abstract = {Ecological relationships between bacteria mediate the  services that gut microbiomes provide to their hosts.  Knowing the overall direction and strength of these  relationships is essential to learn how ecology scales up  to affect microbiome assembly, dynamics, and host health.  However, whether bacterial relationships are generalizable  across hosts or personalized to individual hosts is  debated. Here, we apply a robust, multinomial  logistic-normal modeling framework to extensive time series  data (5534 samples from 56 baboon hosts over 13 years) to  infer thousands of correlations in bacterial abundance in  individual baboons and test the degree to which bacterial  abundance correlations are ‘universal’. We also compare  these patterns to two human data sets. We find that, most  bacterial correlations are weak, negative, and universal  across hosts, such that shared correlation patterns  dominate over host-specific correlations by almost twofold.  Further, taxon pairs that had inconsistent correlation  signs (either positive or negative) in different hosts  always had weak correlations within hosts. From the host  perspective, host pairs with the most similar bacterial  correlation patterns also had similar microbiome taxonomic  compositions and tended to be genetic relatives. Compared  to humans, universality in baboons was similar to that in  human infants, and stronger than one data set from human  adults. Bacterial families that showed universal  correlations in human infants were often universal in  baboons. Together, our work contributes new tools for  analyzing the universality of bacterial associations across  hosts, with implications for microbiome personalization,  community assembly, and stability, and for designing  microbiome interventions to improve host health.},
      url = {http://knowledge.uchicago.edu/record/6622},
}