@article{TEXTUAL,
      recid = {6557},
      author = {Jovic, Katharina and Sterken, Mark G. and Grilli, Jacopo  and Bevers, Roel P. J. and Rodriguez, Miriam and Riksen,  Joost A. G. and Allesina, Stefano and Kammenga, Jan E. and  Snoek, L. Basten},
      title = {Temporal dynamics of gene expression in heat-stressed  <i>Caenorhabditis elegans</i>},
      journal = {PLOS ONE},
      address = {2017-12-11},
      number = {TEXTUAL},
      abstract = {There is considerable insight into pathways and genes  associated with heat-stress conditions. Most genes involved  in stress response have been identified using mutant  screens or gene knockdowns. Yet, there is limited  understanding of the temporal dynamics of global gene  expression in stressful environments. Here, we studied  global gene expression profiles during 12 hours of heat  stress in the nematode C. elegans. Using a high-resolution  time series of increasing stress exposures, we found a  distinct shift in gene expression patterns between 3–4  hours into the stress response, separating an initially  highly dynamic phase from a later relatively stagnant  phase. This turning point in expression dynamics coincided  with a phenotypic turning point, as shown by a strong  decrease in movement, survival and, progeny count in the  days following the stress. Both detectable at  transcriptional and phenotypic level, this study pin-points  a relatively small time frame during heat stress at which  enough damage is accumulated, making it impossible to  recover the next few days.},
      url = {http://knowledge.uchicago.edu/record/6557},
}