@article{TEXTUAL,
      recid = {6318},
      author = {D'Souza, M. Patricia and Adams, Erin and Altman, John D.  and Birnbaum, Michael E. and Boggiano, Cesar and Casorati,  Giulia and Chien, Yueh-hsiu and Conley, Anthony and Guiomar  Eckle, Sidonia Barbara and Früh, Klaus and Gondré-Lewis,  Timothy and Hassan, Namir and Huang, Huang and Jayashankar,  Lakshmi and Kasmar, Anne G. and Kunwar, Nina and Lavelle,  Judith and Lewinsohn, David M. and Moody, Branch and  Picker, Louis},
      title = {Casting a wider net: Immunosurveillance by nonclassical  MHC molecules},
      journal = {PLOS Pathogens},
      address = {2019-02-21},
      number = {TEXTUAL},
      abstract = {Most studies of T lymphocytes focus on recognition of  classical major histocompatibility complex (MHC) class I or  II molecules presenting oligopeptides, yet there are  numerous variations and exceptions of biological  significance based on recognition of a wide variety of  nonclassical MHC molecules. These include αβ and γδ T cells  that recognize different class Ib molecules (CD1, MR-1,  HLA-E, G, F, et al.) that are nearly monomorphic within a  given species. Collectively, these T cells can be  considered “unconventional,” in part because they recognize  lipids, metabolites, and modified peptides. Unlike  classical MHC-specific cells, unconventional T cells  generally exhibit limited T-cell antigen receptor (TCR)  repertoires and often produce innate immune cell-like rapid  effector responses. Exploiting this system in new  generation vaccines for human immunodeficiency virus (HIV),  tuberculosis (TB), other infectious agents, and cancer was  the focus of a recent workshop, “Immune Surveillance by  Non-classical MHC Molecules: Improving Diversity for  Antigens,” sponsored by the National Institute of Allergy  and Infectious Diseases. Here, we summarize salient points  presented regarding the basic immunobiology of  unconventional T cells, recent advances in methodologies to  measure unconventional T-cell activity in diseases, and  approaches to harness their considerable clinical  potential.},
      url = {http://knowledge.uchicago.edu/record/6318},
}