@article{TEXTUAL,
      recid = {6253},
      author = {Mace, Kieran and Krakowiak, Joanna and El-Samad, Hana and  Pincus, David},
      title = {Multi-kinase control of environmental stress responsive  transcription},
      journal = {PLOS ONE},
      address = {2020-03-11},
      number = {TEXTUAL},
      abstract = {Cells respond to changes in environmental conditions by  activating signal transduction pathways and gene expression  programs. Here we present a dataset to explore the  relationship between environmental stresses, kinases, and  global gene expression in yeast. We subjected 28  drug-sensitive kinase mutants to 10 environmental  conditions in the presence of inhibitor and performed mRNA  deep sequencing. With these data, we reconstructed  canonical stress pathways and identified examples of  crosstalk among pathways. The data also implicated numerous  kinases in novel environment-specific roles. However,  rather than regulating dedicated sets of target genes,  individual kinases tuned the magnitude of induction of the  environmental stress response (ESR)–a gene expression  signature shared across the set of perturbations–in  environment-specific ways. This suggests that the ESR  integrates inputs from multiple sensory kinases to modulate  gene expression and growth control. As an example, we  provide experimental evidence that the high osmolarity  glycerol pathway is an upstream negative regulator of  protein kinase A, a known inhibitor of the ESR. These  results elaborate the central axis of cellular stress  response signaling.},
      url = {http://knowledge.uchicago.edu/record/6253},
}