@article{TEXTUAL,
      recid = {6243},
      author = {Grasselli, Giorgio and Boele, Henk-Jan and Titley, Heather  K. and Bradford, Nora and van Beers, Lisa and Jay, Lindsey  and Beekhof, Gerco C. and Busch, Silas E. and De Zeeuw,  Chris I. and Schonewille, Martijn and Hansel, Christian},
      title = {SK2 channels in cerebellar Purkinje cells contribute to  excitability modulation in motor-learning–specific memory  traces},
      journal = {PLOS Biology},
      address = {2020-01-06},
      number = {TEXTUAL},
      abstract = {Neurons store information by changing synaptic input  weights. In addition, they can adjust their membrane  excitability to alter spike output. Here, we demonstrate a  role of such “intrinsic plasticity” in behavioral learning  in a mouse model that allows us to detect specific  consequences of absent excitability modulation. Mice with a  Purkinje-cell–specific knockout (KO) of the  calcium-activated K+ channel SK2 (L7-SK2) show intact  vestibulo-ocular reflex (VOR) gain adaptation but impaired  eyeblink conditioning (EBC), which relies on the ability to  establish associations between stimuli, with the eyelid  closure itself depending on a transient suppression of  spike firing. In these mice, the intrinsic plasticity of  Purkinje cells is prevented without affecting long-term  depression or potentiation at their parallel fiber (PF)  input. In contrast to the typical spike pattern of  EBC-supporting zebrin-negative Purkinje cells, L7-SK2  neurons show reduced background spiking but enhanced  excitability. Thus, SK2 plasticity and excitability  modulation are essential for specific forms of motor  learning.},
      url = {http://knowledge.uchicago.edu/record/6243},
}