@article{TEXTUAL,
      recid = {6227},
      author = {Powell-Roach, Keesha L. and Yao, Yingwei and Jhun, Ellie  H. and He, Ying and Suarez, Marie L. and Ezenwa, Miriam O.  and Molokie, Robert E. and Wang, Zaijie Jim and Wilkie,  Diana J.},
      title = {Vasopressin SNP pain factors and stress in sickle cell  disease},
      journal = {PLOS ONE},
      address = {2019-11-11},
      number = {TEXTUAL},
      abstract = {<p>Purpose: Frequencies of single nucleotide polymorphisms  (SNPs) from pain related candidate genes are available for  individuals with sickle cell disease (SCD). One of those  genes, the arginine vasopressin receptor 1A gene (AVPR1A)  and one of its SNPs, rs10877969, has been associated with  pain and disability in other pain populations. In patients  with SCD, clinical factors such as pain and stress have  been associated with increased health care utilization, but  it is not known if the presence of the AVPR1A SNP plays a  role in this observation. The study purpose was to explore  the relationships between rs10877969 and self-reported  pain, stress, and acute care utilization events among  individuals with SCD.</p> <p>Methods: In a cross-sectional  investigation of outpatients with SCD, participants  completed PAINReportItĀ®, a computerized pain measure, to  describe their pain experience and contributed blood or  saliva samples for genetic analysis. We extracted emergency  department and acute care utilization from medical  records.</p> <p>Results: The SNP genotype frequencies (%)  for this sample were CC 30 (28%), CT 44 (41%), TT 33 (31%).  Acute care utilization and stress as an aggravator of pain  were significantly associated with the rs10877969 genotype  (p = .02 and p = .002, respectively). The CT genotype had  the highest mean utilization and CC genotype was associated  with not citing stress as a pain aggravator. Chronic pain  was not associated with rs10877969 (p = .41).</p>  <p>Conclusion: This study shows that rs10877969 is related  to indicators of stress and acute pain. Further research is  recommended with other measures of stress and acute  pain.</p>},
      url = {http://knowledge.uchicago.edu/record/6227},
}