@article{THESIS,
      recid = {6114},
      author = {Fletcher, Presley},
      title = {The relationship between the subjective, behavioral, and  physiological responses to methamphetamine administration  in humans},
      publisher = {University of Chicago},
      school = {M.A.},
      address = {2023-06},
      number = {THESIS},
      abstract = {It is important to investigate the factors contributing to  continued use of methamphetamines (METH) considering the  recent rise in psychostimulant deaths in the United States  and health risks. While previous research has characterized  specific responses to METH, such as increases in blood  pressure and elevated mood, the current study aims to  implement a multi-dimensional approach assessing behavioral  reward related task responses, subjective questionnaire  responses, and physiological blood pressure reads to  understand the neurochemical basis of METH administration  (20mg) in 51 healthy men and women between the ages of 18  and 35. We examined correlations comparing these three  measures predicting the drug responses to be related to  distinct underlying processes, dopaminergic and  noradrenergic respectively. We found upon METH  administration, participants experienced positive  subjective responses, increased cardiovascular activity,  and alterations in cognitive processes inducing a greater  willingness to exert effort for reward. Our hypothesis was  partially supported with marginally positive associations  between subjective ratings and task-related responses.  There were inconsistencies in the relationship between  subjective ratings and blood pressure reads, with one  questionnaire (Drug Effects Questionnaire), demonstrating a  positive association, and another (euphoric measure)  failing to demonstrate a relationship. Surprisingly, the  behavioral reward-related task and blood pressure reads  demonstrated a positive association. Based on these  results, we conclude that the underlying processes  associated with METH responses in drug taking behavior are  not dissociable.},
      url = {http://knowledge.uchicago.edu/record/6114},
      doi = {https://doi.org/10.6082/uchicago.6114},
}