@article{TEXTUAL,
      recid = {5979},
      author = {van Gent, Michiel and Reich, Adrian and Velu, Sadanandan  E. and Gack, Michaela U.},
      title = {Nonsense-mediated decay controls the reactivation of the  oncogenic herpesviruses EBV and KSHV},
      journal = {PLOS Biology},
      address = {2021-02-17},
      number = {TEXTUAL},
      abstract = {<p>The oncogenic human herpesviruses Epstein–Barr virus  (EBV) and Kaposi’s sarcoma-associated herpesvirus (KSHV)  are the causative agents of multiple malignancies. A  hallmark of herpesviruses is their biphasic life cycle  consisting of latent and lytic infection. In this study, we  identified that cellular nonsense-mediated decay (NMD), an  evolutionarily conserved RNA degradation pathway,  critically regulates the latent-to-lytic switch of EBV and  KSHV infection. The NMD machinery suppresses EBV and KSHV  Rta transactivator expression and promotes maintenance of  viral latency by targeting the viral polycistronic  transactivator transcripts for degradation through the  recognition of features in their 3′ UTRs. Treatment with a  small-molecule NMD inhibitor potently induced reactivation  in a variety of EBV- and KSHV-infected cell types. In  conclusion, our results identify NMD as an important host  process that controls oncogenic herpesvirus reactivation,  which may be targeted for the therapeutic induction of  lytic reactivation and the eradication of tumor cells.</p>},
      url = {http://knowledge.uchicago.edu/record/5979},
}