@article{TEXTUAL,
      recid = {5927},
      author = {Friedman, Eleanor E. and Devlin, Samantha A. and McNulty,  Moira C. and Ridgway, Jessica P.},
      title = {SARS-CoV-2 percent positivity and risk factors among  people with HIV at an urban academic medical center},
      journal = {PLOS ONE},
      address = {2021-07-21},
      number = {TEXTUAL},
      abstract = {<p>Since the onset of the COVID-19 pandemic, it has been  unclear how vulnerable people with HIV (PwH) are to  SARS-CoV-2 infection. We sought to determine if PwH are  more likely to test positive for SARS-CoV-2 than people  without HIV, and to identify risk factors associated with  SARS-CoV-2 positivity among PwH. We conducted a  cross-sectional study in which we collected electronic  medical record data for all patients who underwent  SARS-CoV-2 PCR testing at an academic medical center.  Presence of HIV and other chronic diseases were based on  the presence of ICD-10 diagnosis codes. We calculated the  percent positivity for SARS-CoV-2 among PwH and among  people without HIV. Among PwH, we compared demographic  factors, comorbidities, HIV viral load, CD4 T-cell count,  and antiretroviral therapy (ART) regimens between those who  tested positive for SARS-CoV-2 and those who tested  negative. Comparisons were made using chi squared tests or  Wilcoxon rank sum tests. Multivariate models were created  using logistic regression. Among 69,763 people tested for  SARS-CoV-2, 0.6% (431) were PwH. PwH were not significantly  more likely to test positive for SARS-CoV-2 than people  without HIV (7.2% (31/431) vs 8.4% (5820/69763), p = 0.35),  but were more likely to be younger, Black, and male  (p-values < .0001). There were no significant differences  in HIV clinical factors, chronic diseases, or ART regimens  among PwH testing positive for SARS-CoV-2 versus those  testing negative. In our sample, PwH were not more likely  to contract SARS-CoV-2, despite being more likely to be  members of demographic groups known to be at higher risk  for infection. Differences between PwH who tested positive  for SARS-CoV-2 and those who tested negative were only seen  in Hispanic/Latino ethnicity (non-Hispanic or Latino vs  unknown Hispanic or Latino ethnicity (OR 0.2 95% CI (0.6,  0.9)) and site of testing(inpatient vs outpatient OR 3.1  95% CI (1.3, 7.4)).</p>},
      url = {http://knowledge.uchicago.edu/record/5927},
}