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000005593 005__ 20250425034400.0
000005593 02470 $$ahttps://doi.org/10.3390/ijms24054741$$2doi
000005593 037__ $$aTEXTUAL$$bArticle
000005593 041__ $$aeng
000005593 245__ $$aDNA Damage and Its Role in Cancer Therapeutics
000005593 269__ $$a2023-03-01
000005593 336__ $$aArticle
000005593 520__ $$aDNA damage is a double-edged sword in cancer cells. On the one hand, DNA damage exacerbates gene mutation frequency and cancer risk. Mutations in key DNA repair genes, such as breast cancer 1 (BRCA1) and/or breast cancer 2 (BRCA2), induce genomic instability and promote tumorigenesis. On the other hand, the induction of DNA damage using chemical reagents or radiation kills cancer cells effectively. Cancer-burdening mutations in key DNA repair-related genes imply relatively high sensitivity to chemotherapy or radiotherapy because of reduced DNA repair efficiency. Therefore, designing specific inhibitors targeting key enzymes in the DNA repair pathway is an effective way to induce synthetic lethality with chemotherapy or radiotherapy in cancer therapeutics. This study reviews the general pathways involved in DNA repair in cancer cells and the potential proteins that could be targeted for cancer therapeutics.
000005593 536__ $$oNational Research Foundation of Korea (NRF)$$cNRF-2022R1A2C1091563
000005593 536__ $$oNational Research Foundation of Korea (NRF)$$cNRF-2019M3E5D3073092
000005593 536__ $$oNational Research Foundation of Korea (NRF)$$cNRF-2019R1A5A8083404
000005593 536__ $$oSoonchunhyang University$$aResearch Fund
000005593 540__ $$a<p>© 2023 by the authors</p> <p>This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (<a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a>).</p>
000005593 542__ $$fCC BY
000005593 6531_ $$aDNA damage
000005593 6531_ $$acancer therapeutics
000005593 6531_ $$amutations
000005593 690__ $$aBiological Sciences Division
000005593 691__ $$aPathology
000005593 7001_ $$aMoon, Jaeyoung$$uSoonchunhyang University
000005593 7001_ $$aKitty, Ichiwa$$uSoonchunhyang University
000005593 7001_ $$aRenata, Kusuma$$uSoonchunhyang University
000005593 7001_ $$aQin, Sisi$$uUniversity of Chicago
000005593 7001_ $$aZhao, Fei$$uHunan University
000005593 7001_ $$1https://orcid.org/0000-0003-4364-3260$$2ORCID$$aKim, Wootae$$uSoonchunhyang University
000005593 773__ $$tInternational Journal of Molecular Sciences
000005593 8564_ $$9234eed17-3461-4519-bb23-fcdab62e3642$$s1386484$$uhttps://knowledge.uchicago.edu/record/5593/files/DNA-Damage-and-Its-Role-in-Cancer-Therapeutics.pdf$$ePublic
000005593 908__ $$aI agree
000005593 909CO $$ooai:uchicago.tind.io:5593$$pGLOBAL_SET
000005593 983__ $$aArticle