TY  - GEN
AB  - DNA damage is a double-edged sword in cancer cells. On the one hand, DNA damage exacerbates gene mutation frequency and cancer risk. Mutations in key DNA repair genes, such as breast cancer 1 (BRCA1) and/or breast cancer 2 (BRCA2), induce genomic instability and promote tumorigenesis. On the other hand, the induction of DNA damage using chemical reagents or radiation kills cancer cells effectively. Cancer-burdening mutations in key DNA repair-related genes imply relatively high sensitivity to chemotherapy or radiotherapy because of reduced DNA repair efficiency. Therefore, designing specific inhibitors targeting key enzymes in the DNA repair pathway is an effective way to induce synthetic lethality with chemotherapy or radiotherapy in cancer therapeutics. This study reviews the general pathways involved in DNA repair in cancer cells and the potential proteins that could be targeted for cancer therapeutics.
AD  - Soonchunhyang University
AD  - Soonchunhyang University
AD  - Soonchunhyang University
AD  - University of Chicago
AD  - Hunan University
AD  - Soonchunhyang University
AU  - Moon, Jaeyoung
AU  - Kitty, Ichiwa
AU  - Renata, Kusuma
AU  - Qin, Sisi
AU  - Zhao, Fei
AU  - Kim, Wootae
DA  - 2023-03-01
ID  - 5593
JF  - International Journal of Molecular Sciences
KW  - DNA damage
KW  - cancer therapeutics
KW  - mutations
L1  - https://knowledge.uchicago.edu/record/5593/files/DNA-Damage-and-Its-Role-in-Cancer-Therapeutics.pdf
L2  - https://knowledge.uchicago.edu/record/5593/files/DNA-Damage-and-Its-Role-in-Cancer-Therapeutics.pdf
L4  - https://knowledge.uchicago.edu/record/5593/files/DNA-Damage-and-Its-Role-in-Cancer-Therapeutics.pdf
LA  - eng
LK  - https://knowledge.uchicago.edu/record/5593/files/DNA-Damage-and-Its-Role-in-Cancer-Therapeutics.pdf
N2  - DNA damage is a double-edged sword in cancer cells. On the one hand, DNA damage exacerbates gene mutation frequency and cancer risk. Mutations in key DNA repair genes, such as breast cancer 1 (BRCA1) and/or breast cancer 2 (BRCA2), induce genomic instability and promote tumorigenesis. On the other hand, the induction of DNA damage using chemical reagents or radiation kills cancer cells effectively. Cancer-burdening mutations in key DNA repair-related genes imply relatively high sensitivity to chemotherapy or radiotherapy because of reduced DNA repair efficiency. Therefore, designing specific inhibitors targeting key enzymes in the DNA repair pathway is an effective way to induce synthetic lethality with chemotherapy or radiotherapy in cancer therapeutics. This study reviews the general pathways involved in DNA repair in cancer cells and the potential proteins that could be targeted for cancer therapeutics.
PY  - 2023-03-01
T1  - DNA Damage and Its Role in Cancer Therapeutics
TI  - DNA Damage and Its Role in Cancer Therapeutics
UR  - https://knowledge.uchicago.edu/record/5593/files/DNA-Damage-and-Its-Role-in-Cancer-Therapeutics.pdf
Y1  - 2023-03-01
ER  -