@article{TEXTUAL,
      recid = {5593},
      author = {Moon, Jaeyoung and Kitty, Ichiwa and Renata, Kusuma and  Qin, Sisi and Zhao, Fei and Kim, Wootae},
      title = {DNA Damage and Its Role in Cancer Therapeutics},
      journal = {International Journal of Molecular Sciences},
      address = {2023-03-01},
      number = {TEXTUAL},
      abstract = {DNA damage is a double-edged sword in cancer cells. On the  one hand, DNA damage exacerbates gene mutation frequency  and cancer risk. Mutations in key DNA repair genes, such as  breast cancer 1 (BRCA1) and/or breast cancer 2 (BRCA2),  induce genomic instability and promote tumorigenesis. On  the other hand, the induction of DNA damage using chemical  reagents or radiation kills cancer cells effectively.  Cancer-burdening mutations in key DNA repair-related genes  imply relatively high sensitivity to chemotherapy or  radiotherapy because of reduced DNA repair efficiency.  Therefore, designing specific inhibitors targeting key  enzymes in the DNA repair pathway is an effective way to  induce synthetic lethality with chemotherapy or  radiotherapy in cancer therapeutics. This study reviews the  general pathways involved in DNA repair in cancer cells and  the potential proteins that could be targeted for cancer  therapeutics.},
      url = {http://knowledge.uchicago.edu/record/5593},
}