@article{TEXTUAL,
      recid = {4980},
      author = {Mansour, Ali and Loggini, Andrea and El Ammar, Faten and  Alvarado-Dyer, Ronald and Polster, Sean and Stadnik,  Agnieszka and Das, Paramita and Warnke, Peter C. and  Yamini, Bakhtiar and Lazaridis, Christos and Kramer,  Christopher and Mould, W. Andrew and Hildreth, Meghan and  Sharrock, Matthew and Hanley, Daniel F. and Goldenberg,  Fernando D. and Awad, Issam A.},
      title = {Post-Trial Enhanced Deployment and Technical Performance  with the MISTIE Procedure per Lessons Learned},
      journal = {Journal of Stroke and Cerebrovascular Diseases},
      address = {2021-07-22},
      number = {TEXTUAL},
      abstract = {&lt;p&gt;Objective: We hypothesize that procedure deployment  rates and technical performance with minimally invasive  surgery and thrombolysis for intracerebral hemorrhage (ICH)  evacuation (MISTIE) can be enhanced in post-trial clinical  practice, per Phase III trial results and lessons  learned.&lt;/p&gt; &lt;p&gt;Materials and Methods: We identified ICH  patients and those who underwent MISTIE procedure between  2017–2021 at a single site, after completed enrollments in  the Phase III trial. Deployment rates, complications and  technical outcomes were compared to those observed in the  trial. Initial and final hematoma volume were compared  between site measurements using ABC/2, MISTIE trial reading  center utilizing manual segmentation, and a novel  Artificial Intelligence (AI) based volume assessment.&lt;/p&gt;  &lt;p&gt;Results: Nineteen of 286 patients were eligible for  MISTIE. All 19 received the procedure (6.6% enrollment to  screening rate 6.6% compared to 1.6% at our center in the  trial; p=0.0018). Sixteen patients (84%) achieved  evaculation target &lt; 15 mL residual ICH or &gt; 70% removal,  compared to 59.7% in the trial surgical cohort (p=0.034).  No poor catheter placement occurred and no surgical  protocol deviations. Limitations of ICH volume assessments  using the ABC/2 method were shown, while AI based  methodology of ICH volume assessments had excellent  correlation with manual segmentation by experienced reading  centers.&lt;/p&gt; &lt;p&gt;Conclusions: Greater procedure deployment  and higher technical success rates can be achieved in  post-trial clinical practice than in the MISTIE III trial.  AI based measurements can be deployed to enhance clinician  estimated ICH volume. Clinical outcome implications of this  enhanced technical performance cannot be surmised, and will  need assessment in future trials.&lt;/p&gt;},
      url = {http://knowledge.uchicago.edu/record/4980},
}