@article{THESIS,
      recid = {4036},
      author = {Cassaidy, Kyle John},
      title = {A Cycloisomerization Strategy for the De Novo Synthesis of  Steroidal Alkaloids},
      publisher = {University of Chicago},
      school = {Ph.D.},
      address = {2022-06},
      number = {THESIS},
      pages = {388},
      abstract = {A strategy that leverages a [2+2+2] cycloisomerization to  open de novo access to the Veratrum family of alkaloids has  been developed and deployed to achieve the total synthesis  of steroidal alkaloids. The highly convergent approach  described herein includes (i) the enantioselective  synthesis of a diyne fragment containing the steroidal A/B  rings, (ii) the asymmetric synthesis of a  propargyl-substituted piperidinone (F ring) unit, (iii) the  high-yielding union of the above fragments, and (iv) the  intramolecular [2+2+2] cycloisomerization reaction of the  resulting carbon framework to construct in a single step  the remaining three rings (C/D/E) of the hexacyclic  cevanine skeleton. From a common cevanine-type  intermediate, two concise approaches toward other members  of this important family of steroidal alkaloids have been  devised, both of which rely on skeletal reorganization. },
      url = {http://knowledge.uchicago.edu/record/4036},
      doi = {https://doi.org/10.6082/uchicago.4036},
}