@article{Sex-Specific:3442,
      recid = {3442},
      author = {Hansen, Grace},
      title = {Repeat Elements and Novel Genes Contribute to Sex-Specific  Mechanisms of Metabolism},
      publisher = {University of Chicago},
      school = {Ph.D.},
      address = {2021-08},
      pages = {111},
      abstract = {Obesity-associated mortality is exacerbated by high  abdominal obesity. Here, we identify genes associated with  obesity and waist-to-hip ratio adjusted for body mass index  (WHRadjBMI), and allele-sensitive enhancers which are  predicted to regulate female WHRadjBMI genes. 76% (45/59)  of obesity and waist-to-hip ratio-associated variants are  located in primate-specific Alu elements which contain a  motif associated with adipocyte differentiation. SNX10, the  strongest female WHRadjBMI-associated gene, is required for  adipocyte differentiation and is required for adipose  expansion in female mice, but not males, and the lead  variant at the SNX10 locus affects intracellular lipids in  human adipocytes. In conclusion, we find novel genes and a  system of gene regulatory elements which regulate adipocyte  differentiation and may affect human health.},
      url = {http://knowledge.uchicago.edu/record/3442},
      doi = {https://doi.org/10.6082/uchicago.3442},
}