@article{THESIS,
      recid = {2935},
      author = {Onishi, Kenneth Gayosa},
      title = {Transkingdom Interactions Regulate Behavior across the  Lifespan},
      publisher = {University of Chicago},
      school = {Ph.D.},
      address = {2021-06},
      number = {THESIS},
      pages = {209},
      abstract = {Every mammalian cell in the body contains a timekeeper – a  molecular clock that tracks time-of-day information. It is  well-established that interactions between central (SCN)  and peripheral oscillators can influence the mammalian  circadian rhythms in physiology and behavior. These  experiments examine how the environment influences  circadian rhythms in both behavior and physiology. Chapter  3 tests the hypothesis that the gut microbiota is a  component of the circadian network by chronotyping mice  born and reared devoid of bacteria (germ free mice) and  comparing those to ‘normal’ SPF mice. Chapter 4 examines  the role of gut microbiota in mediating the effects of high  fat diet on circadian rhythms by chronotyping both  bacterially replete and germ free mice fed either a normal  chow or high fat diet. Chapter 5 examines the influence of  gestational sickness on circadian rhythms in mice with  different gut microbiota composition, using a mouse model  of maternal immune activation in mice obtained from  different rodent vendors known for their differential  presence of gut microbiota species. Chapter 6 examines  interacting timescales that generate seasonal rhythms in  immune function. Seasonally breeding rodents, Siberian  hamsters (Phodopus sungorus) were immune challenged every  three hours of the circadian cycle in both winterlike and  summerlike photocycles. Chapter 6 examines both innate and  adaptive immune traits and how seasonal and daily  timescales interact to produce rhythmic changes in immune  function. Together, these experiments explore transkingdom  interactions and their influence on host behavior. },
      url = {http://knowledge.uchicago.edu/record/2935},
      doi = {https://doi.org/10.6082/uchicago.2935},
}