@article{Stress-Associated:2591,
      recid = {2591},
      author = {Triandafillou, Catherine Genevieve},
      title = {Stress-Associated Intracellular Acidification Is Adaptive},
      publisher = {The University of Chicago},
      school = {Ph.D.},
      address = {2020-08},
      pages = {112},
      abstract = {Exposure to high temperatures induces many changes in  cells, including the induction of a transcriptional program  regulated by the highly-conserved transcription factor Heat  Shock Factor 1 (Hsf1). In a wide range of eukaryotes,  stress also triggers transient intracellular acidification  which, by unknown mechanisms, is associated with increased  survival. Activation of the Hsf1-mediated heat shock  response can be triggered by misfolding of newly  synthesized polypeptides, and so has been thought to depend  on ongoing protein synthesis. I have discovered that even  in the absence of ongoing translation,  heat-shock-associated cytosolic acidification specifically  promotes the activation of Hsf1 in budding yeast.  Additionally, preventing cells from transiently acidifying  during heat shock compromises fitness, demonstrating that  intracellular acidification is adaptive. These results  imply the existence of non-canonical triggers for the  response and additional contributions to cellular fitness  beyond the repair of stress-induced damage.},
      url = {http://knowledge.uchicago.edu/record/2591},
      doi = {https://doi.org/10.6082/uchicago.2591},
}