@article{THESIS,
      recid = {2209},
      author = {Advani, Alexander},
      title = {Reading-Frame Shift Mechanisms of Introducing Genetic  Novelty to the Human Genome},
      publisher = {University of Chicago},
      school = {Ph.D.},
      address = {2020-06},
      number = {THESIS},
      pages = {197},
      abstract = {How genetic novelty arises is one of the most elusive  questions within genetics and has implications across  numerous and diverse fields. Although there are many  possible answers, reading frame-shifts in protein-coding  DNA are known to create dramatically different peptides and  have the potential to enable large evolutionary steps. The  radical nature of these mutations have led to the  assumption that they do not often survive and are strongly  selected against. Nevertheless, when they occur in a  duplicated gene, many of the negative selective pressures  are alleviated. In this thesis I use a conservative method  which proves that this is a mechanism by which genetic  material has been commonly introduced to the human genome.  In addition, I determine the characteristics which human  genes formed by this mechanism most commonly share and the  roles they have played in human evolution. Finally, I  discuss the effects of frameshifting and the cooption of  frameshifted genes on human evolution and more broadly  genomic adaptation across the tree of life.},
      url = {http://knowledge.uchicago.edu/record/2209},
      doi = {https://doi.org/10.6082/uchicago.2209},
}