@article{Rhodium-Catalyzed:1874,
      recid = {1874},
      author = {Deng, Lin},
      title = {Rhodium-Catalyzed C−C Bond Activation of Four-Membered  Ring Ketones},
      publisher = {The University of Chicago},
      school = {Ph.D.},
      address = {2019-06},
      pages = {529},
      abstract = {Transition metal-catalyzed C−C σ-bond cleavage of cyclic  compounds followed by 2π-insertion, namely a “cut-and-sew”  approach, has recently emerged as an attractive approach  for complex bridged or fused ring formation. Comparing with  traditional approaches, these methods operate at near pH  and redox neutral conditions, and usually in a highly  atom-economical manner. In this thesis, introduction of the  history and recent advancement in the field was provided.  Based on the current limitations of this approach, we  designed and realized the enantioselective carboacylation  of C=N bonds and C=C bonds through C−C activation of  benzocyclobutenones and applied this new approach to the  asymmetric total synthesis of (−)-cycloclavine. In  addition, the racemic and enantioselective "cut-and-sew"  reactions between the alkynes or olefins and the  alfa-branched cyclobutanones were developed.},
      url = {http://knowledge.uchicago.edu/record/1874},
      doi = {https://doi.org/10.6082/uchicago.1874},
}