@article{Post-Transcriptional:1550,
      recid = {1550},
      author = {Roundtree, Ian},
      title = {Post-Transcriptional Gene Regulation by N6-Methyladenosine  and Selective RNA Binding Proteins},
      publisher = {University of Chicago},
      school = {Ph.D.},
      address = {2017-12},
      pages = {137},
      abstract = {Regulation of genetic output is a complex biological  phenomenon that allows cells with identical genetic  material to enable diverse phenotypic outcomes. Epigenetics  is the study of factors that change gene expression without  perturbing the underlying genetic sequence. Mechanisms of  epigenetics feature a multitude of chemical modifications  to DNA as well as accompanying histone proteins, which tune  the transcriptional output in a reversible manner.  Recently, the concept of reversible RNA epigenetics has  emerged as a mechanism to regulate gene expression  post-transcriptionally. N6-methylasdenosein (m6A) is the  most common internal modification in eukaryotic messenger  RNA (mRNA). This RNA modification is recognized by  m6A-selective RNA binding protein of the YTH family, which  incorporate modified RNAs into canonical pathways for mRNA  metabolism. In this work, we describe the function of the  only nuclear YTH protein YTHDC1 in promoting the nuclear  export of methylated mRNAs by interaction with the splicing  and export adaptor protein SRSF3. We then turn to a  biological example of rapid mRNA processing during  progression through the cell cycle. We propose that m6A  modifications serve roles in the dynamic regulation of the  cellular transcriptome.},
      url = {http://knowledge.uchicago.edu/record/1550},
      doi = {https://doi.org/10.6082/uchicago.1550},
}