@article{TEXTUAL,
      recid = {14615},
      author = {Yanofsky, Russell and Rubin, David T.},
      title = {A practical approach to positioning therapies in  ulcerative colitis},
      journal = {Journal of the Canadian Association of Gastroenterology},
      address = {2025-02-21},
      number = {TEXTUAL},
      abstract = {The therapeutic landscape of ulcerative colitis (UC) has  undergone significant change over the last 2 decades. While  there are multiple new therapies for the management of UC,  long-term remission rates remain low, and this may be in  part due to the difficulty of navigating a successful  treatment strategy. In this review, we propose a rational  framework for treatment selection, sequencing, and  optimization in patients with UC. We outline treatment  goals and targets for UC, followed by a discussion of the  challenges in treatment selection and considerations to  help guide a sequencing strategy. These include an  assessment of a therapy’s efficacy and safety, the  convenience in the delivery of the therapy, ease of access,  and patient-related factors. We then provide an overview of  the currently approved therapies for UC, with an in-depth  analysis of their advantages and disadvantages. Finally, we  conclude with future directions in the management of UC,  which include the use of naturopathic therapies, faecal  microbiota therapy, the use of precision medicine, and  other strategies such as combination therapy.},
      url = {http://knowledge.uchicago.edu/record/14615},
}