@article{TEXTUAL, recid = {14612}, author = {Spring, Jessica and Gurbuxani, Sandeep and Golovkina, Tatyana}, title = {Microbiota does not influence tumor development in two models of heritable cancer}, journal = {mBio}, address = {2025-02-19}, number = {TEXTUAL}, abstract = {Microbial impact on tumorigenesis of heritable cancers proximal to the gut is well-documented. Whether the microbiota influences cancers arising from inborn mutations at sites distal to the gut is undetermined. Using two models of heritable cancer, Trp53-deficient mice and Wnt1-transgenic mice, and a gnotobiotic approach, we found the microbiota to be inconsequential for tumor development. This work furthers our understanding of the degree of the microbial impact on tumor development.}, url = {http://knowledge.uchicago.edu/record/14612}, }