@article{TEXTUAL,
      recid = {14497},
      author = {Wu, Wen and Zhang, Jian and Qu, Xiao and Chen, Ting and  Li, Jinming and Yang, Yongzhi and Chen, Lifeng and Hoover,  Alex and Guo, Fanying and Kong, Cheng and Bao, Bingkun and  Lin, Qiuning and Zhou, Mengxin and Zhu, Linyong and Wu,  Xiaoyang and Ma, Yanlei},
      title = {Enabling Targeted Drug Delivery for Treatment of  Ulcerative Colitis with Mucosal-Adhesive Photoreactive  Hydrogel},
      journal = {Advanced Science},
      address = {2025-02-03},
      number = {TEXTUAL},
      abstract = {Ulcerative colitis (UC) is a chronic inflammatory bowel  disease. UC treatments are limited by significant adverse  effects associated with non-specific drug delivery, such as  systematic inhibition of the host immune system. Endoscopic  delivery of a synthetic hydrogel material with  biocompatible gelation that can efficiently cover irregular  tissue surfaces provides an effective approach for targeted  drug delivery at the gastrointestinal (GI) tract. An ideal  integration of synthetic material with intestinal  epithelium entails an integrated and preferable chemically  bonded interface between the hydrogel and mucosal surface.  In this study, a photo-triggered coupling reaction is  leveraged as the crosslinking platform to develop a  mucosal-adhesive hydrogel, which is compatible with  endoscope-directed drug delivery for UC treatment. The  results demonstrated superior spatiotemporal specificity  and drug pharmacokinetics with this delivery system in  vivo. Delivery of different drugs with the hydrogel leads  to greatly enhanced therapeutic efficacy and significantly  reduced systemic drug exposure with rat colitis models. The  study presents a strategy for targeted and persistent drug  delivery for UC treatment.},
      url = {http://knowledge.uchicago.edu/record/14497},
}