@article{TEXTUAL,
      recid = {13435},
      author = {Toparlak, Ö. Duhan and Sebastianelli, Lorenzo and Ortuno,  Veronica Egas and Karki, Megha and Xing, Yanfeng and  Szostak, Jack W. and Krishnamurthy, Ramanarayanan and  Mansy, Sheref S.},
      title = {Cyclophospholipids Enable a Protocellular Life Cycle},
      journal = {ACS Nano},
      address = {2023-12-01},
      number = {TEXTUAL},
      abstract = {There is currently no plausible path for the emergence of  a self-replicating protocell, because prevalent  formulations of model protocells are built with fatty acid  vesicles that cannot withstand the concentrations of  Mg<sup>2+</sup> needed for the function and replication of  nucleic acids. Although prebiotic chelates increase the  survivability of fatty acid vesicles, the resulting model  protocells are incapable of growth and division. Here, we  show that protocells made of mixtures of cyclophospholipids  and fatty acids can grow and divide in the presence of  Mg<sup>2+</sup>-citrate. Importantly, these protocells  retain encapsulated nucleic acids during growth and  division, can acquire nucleotides from their surroundings,  and are compatible with the nonenzymatic extension of an  RNA oligonucleotide, chemistry needed for the replication  of a primitive genome. Our work shows that prebiotically  plausible mixtures of lipids form protocells that are  active under the conditions necessary for the emergence of  Darwinian evolution.},
      url = {http://knowledge.uchicago.edu/record/13435},
}