@article{TEXTUAL,
      recid = {13390},
      author = {Yang, Kin S. and Rawal, Viresh H.},
      title = {Synthesis of α-Amino Acid Derivatives and Peptides via  Enantioselective Addition of Masked Acyl Cyanides to  Imines},
      journal = {Journal of the American Chemical Society},
      address = {2014-11-07},
      number = {TEXTUAL},
      abstract = {A general, asymmetric synthesis of amino acid derivatives  is reported. Masked acyl cyanide (MAC) reagents are shown  to be effective umpolung synthons for enantioselective  additions to N-Boc-aldimines. The reactions are catalyzed  by a modified cinchona alkaloid, which can function as a  bifunctional, hydrogen bonding catalyst, and afford adducts  in excellent yields (90–98%) and high enantioselectivities  (up to 97.5:2.5 er). Unmasking the addition products gives  acyl cyanide intermediates that are intercepted by a  variety of nucleophiles to afford α-amino acid derivatives.  Notably, the methodology provides an alternative method for  peptide bond formation.},
      url = {http://knowledge.uchicago.edu/record/13390},
}