@article{TEXTUAL,
      recid = {13372},
      author = {Pragomi, Pedram and Zhang, Zhongjie and Abe, Sarah Krull  and Islam, Md. Rashedul and Rahman, Md. Shafiur and Saito,  Eiko and Shu, Xiao-Ou and Dabo, Bashir and Pham, Yen  Thi-Hai and Chen, Yu and Gao, Yu-Tang and Koh, Woon-Puay  and Sawada, Norie and Malekzadeh, Reza and Sakata, Ritsu  and Hozawa, Atsushi and Kim, Jeongseon and Kanemura, Seiki  and Nagata, Chisato and You, San-Lin and Ito, Hidemi and  Park, Sue K. and Yuan, Jian-Min and Pan, Wen-Harn and Wen,  Wanqing and Ahsan, Habibul},
      title = {Body Mass Index and Risk of Colorectal Cancer Incidence  and Mortality in Asia},
      journal = {JAMA Network Open},
      address = {2024-08-28},
      number = {TEXTUAL},
      abstract = {&lt;p&gt;Importance: The global burden of obesity is increasing,  as are colorectal cancer (CRC) incidence and mortality.&lt;/p&gt;  &lt;p&gt;Objectives: To assess the association between body mass  index (BMI) and risks of incident CRC and CRC-related death  in the Asian population.&lt;/p&gt; &lt;p&gt;Design, Setting, and  Participants: This cohort study includes data pooled from  17 prospective cohort studies included in The Asia Cohort  Consortium. Cohort enrollment was conducted from January 1,  1984, to December 31, 2002. Median follow-up time was 15.2  years (IQR, 12.1-19.2 years). Data were analyzed from  January 15, 2023, through January 15, 2024.&lt;/p&gt;  &lt;p&gt;Exposure: Body mass index, calculated as weight in  kilograms divided by height in meters squared.&lt;/p&gt; &lt;p&gt;Main  Outcomes and Measures: The primary outcomes were CRC  incidence and CRC-related mortality. The risk of events is  reported as adjusted hazard ratios (AHRs) and 95% CIs for  incident CRC and death from CRC using the Cox proportional  hazards regression model.&lt;/p&gt; &lt;p&gt;Results: To assess the  risk of incident CRC, 619 981 participants (mean [SD] age,  53.8 [10.1] years; 52.0% female; 11 900 diagnosed incident  CRC cases) were included in the study, and to assess  CRC-related mortality, 650 195 participants (mean [SD] age,  53.5 [10.2] years; 51.9% female; 4550 identified CRC  deaths) were included in the study. A positive association  between BMI and risk of CRC was observed among participants  with a BMI greater than 25.0 to 27.5 (AHR, 1.09 [95% CI,  1.03-1.16]), greater than 27.5 to 30.0 (AHR, 1.19 [95% CI,  1.11-1.29]), and greater than 30.0 (AHR, 1.32 [95% CI,  1.19-1.46]) compared with those with a BMI greater than  23.0 to 25.0 (P &lt; .001 for trend), and BMI was associated  with a greater increase in risk for colon cancer than for  rectal cancer. A similar association between BMI and  CRC-related death risk was observed among participants with  a BMI greater than 27.5 (BMI &gt;27.5-30.0: AHR, 1.18 [95% CI,  1.04-1.34]; BMI &gt;30.0: AHR, 1.38 [95% CI, 1.18-1.62];  P &lt; .001 for trend) and was present among men with a BMI  greater than 30.0 (AHR, 1.87 [95% CI, 1.49-2.34]; P &lt; .001  for trend) but not among women (P = .15 for trend) (P = .02  for heterogeneity).&lt;/p&gt; &lt;p&gt;Conclusions and Relevance: In  this cohort study that included a pooled analysis of 17  cohort studies comprising participants across Asia, a  positive association between BMI and CRC incidence and  related mortality was found. The risk was greater among men  and participants with colon cancer. These findings may have  implications to better understand the burden of obesity on  CRC incidence and related deaths in the Asian  population.&lt;/p&gt;},
      url = {http://knowledge.uchicago.edu/record/13372},
}