@article{TEXTUAL,
      recid = {13322},
      author = {Lau, Carus H. Y. and Flood, Emelie and Hunter, Mark J. and  Williams-Noonan, Billy J. and Corbett, Karen M. and Ng,  Chai-Ann and Bouwer, James C. and Stewart, Alastair G. and  Perozo, Eduardo and Allen, Toby W. and Vandenberg, Jamie  I.},
      title = {Potassium dependent structural changes in the selectivity  filter of HERG potassium channels},
      journal = {Nature Communications},
      address = {2024-08-29},
      number = {TEXTUAL},
      abstract = {The fine tuning of biological electrical signaling is  mediated by variations in the rates of opening and closing  of gates that control ion flux through different ion  channels. Human ether-a-go-go related gene (HERG) potassium  channels have uniquely rapid inactivation kinetics which  are critical to the role they play in regulating cardiac  electrical activity. Here, we exploit the K<sup>+</sup>  sensitivity of HERG inactivation to determine structures of  both a conductive and non-conductive selectivity filter  structure of HERG. The conductive state has a canonical  cylindrical shaped selectivity filter. The non-conductive  state is characterized by flipping of the selectivity  filter valine backbone carbonyls to point away from the  central axis. The side chain of S620 on the pore helix  plays a central role in this process, by coordinating  distinct sets of interactions in the conductive,  non-conductive, and transition states. Our model represents  a distinct mechanism by which ion channels fine tune their  activity and could explain the uniquely rapid inactivation  kinetics of HERG.},
      url = {http://knowledge.uchicago.edu/record/13322},
}