@article{TEXTUAL,
      recid = {13319},
      author = {Jeitler, Ramona and Glader, Christina and König, Gerhard  and Kaplan, Jay and Tetyczka, Carolin and Remmelgas, Johan  and Mußbacher, Marion and Fröhlich, Eleanore and Roblegg,  Eva},
      title = {On the Structure, Stability, and Cell Uptake of  Nanostructured Lipid Carriers for Drug Delivery},
      journal = {Molecular Pharmaceutics},
      address = {2024-06-05},
      number = {TEXTUAL},
      abstract = {The efficacy of nanostructured lipid carriers (NLC) for  drug delivery strongly depends on their stability and cell  uptake. Both properties are governed by their compositions  and internal structure. To test the effect of the lipid  composition of NLC on cell uptake and stability, three  kinds of liquid lipids with different degrees of  unsaturation are employed. After ensuring homogeneous size  distributions, the thermodynamic characteristics,  stability, and mixing properties of NLC are characterized.  Then the rates and predominant pathways of cell uptake are  determined. Although the same surfactant is used in all  cases, different uptake rates are observed. This finding  contradicts the view that the surface properties of NLC are  dominated by the surfactant. Instead, the uptake rates are  explained by the structure of the nanocarrier. Depending on  the mixing properties, some liquid lipids remain inside the  nanocarrier, while other liquid lipids are present on the  surface. Nanocarriers with liquid lipids on the surface are  taken up more readily by the cells. This shows that the  engineering of efficient lipid nanocarriers requires a  delicate balance of interactions between all components of  the nanocarrier on the molecular level.},
      url = {http://knowledge.uchicago.edu/record/13319},
}