@article{TEXTUAL,
      recid = {13318},
      author = {Saleem Mughal, Muhammad and Akbar Mughal, Tafail and  Sulaiman, Sulaiman and Abd-Elkader, Omar H. and Sayed,  Shaban R. M. and Sidky, Ahmed M. and Akram, Bilal and Khan,  Bilal Ahmad and Ibrahim, Mahmoud A. A.},
      title = {Synthesis and Characterization of Naproxen Intercalated  Zinc Oxide Stacked Nanosheets for Enhanced Hepatoprotective  Potential},
      journal = {ACS Omega},
      address = {2024-05-13},
      number = {TEXTUAL},
      abstract = {Liver diseases pose a significant global health burden,  with limited therapeutic options for chronic cases. Zinc  oxide (ZnO) nanomaterials have emerged as promising  candidates for hepatoprotection due to their antioxidant,  anti-inflammatory, and regenerative properties. However,  their potential remains hampered by insufficient drug  loading and controlled release. The current study explores  the intercalation of Naproxen (Nx), a potent  anti-inflammatory and analgesic drug, within ZnO stacked  nanosheets (SNSs) to address these limitations. Herein, an  easy and solution-based synthesis of novel Nx intercalated  ZnO SNSs was established. The obtained Nx intercalated ZnO  SNSs were encapsulated with poly(vinyl acetate) (PVA) to  make them biocompatible. The synthesized biocomposite was  characterized using X-ray diffraction (XRD), scanning  electron microscopy (SEM), and Fourier transform infrared  spectroscopy (FTIR), which confirm the successful synthesis  and intercalation of Nx within the ZnO SNSs. The obtained  outcomes showed that the configuration of ZnO nanosheets  was altered when Nx was introduced, resulting in a more  organized stacking pattern. An in vivo investigation of  mice liver cells unveiled that the Nx intercalated ZnO SNss  had increased hepatoprotective properties. The study’s  results provide valuable insights into using Nx  intercalated ZnO SNss for targeted drug delivery and  improved treatment effectiveness, particularly for  liver-related illnesses.},
      url = {http://knowledge.uchicago.edu/record/13318},
}