@article{TEXTUAL,
      recid = {13285},
      author = {Mihailescu, Sylvia and Hlava, Quinn and Cook, Philip A.  and Mandelli, Maria Luisa and Lee, Suzee E. and Boeve,  Bradley F. and Dickerson, Bradford C. and Gorno-Tempini,  Maria Luisa and Rogalski, Emily and Grossman, Murray and  Gee, James and McMillan, Corey T. and Olm, Christopher A.},
      title = {Boundary-based registration improves sensitivity for  detecting hypoperfusion in sporadic frontotemporal lobar  degeneration},
      journal = {Frontiers in Neurology},
      address = {2024-08-20},
      number = {TEXTUAL},
      abstract = {&lt;p&gt;Introduction: Frontotemporal lobar degeneration (FTLD)  is associated with FTLD due to tau (FTLD-tau) or TDP  (FTLD-TDP) inclusions found at autopsy. Arterial Spin  Labeling (ASL) MRI is often acquired in the same session as  a structural T1-weighted image (T1w), enabling detection of  regional changes in cerebral blood flow (CBF). We  hypothesize that ASL-T1w registration with more degrees of  freedom using boundary-based registration (BBR) will better  align ASL and T1w images and show increased sensitivity to  regional hypoperfusion differences compared to manual  registration in patient participants. We hypothesize that  hypoperfusion will be associated with a clinical measure of  disease severity, the FTLD-modified clinical dementia  rating scale sum-of-boxes (FTLD-CDR).&lt;/p&gt; &lt;p&gt;Materials and  methods: Patients with sporadic likely FTLD-tau (sFTLD-tau;  N = 21), with sporadic likely FTLD-TDP (sFTLD-TDP; N = 14),  and controls (N = 50) were recruited from the Connectomic  Imaging in Familial and Sporadic Frontotemporal  Degeneration project (FTDHCP). Pearson’s Correlation  Coefficients (CC) were calculated on cortical vertex-wise  CBF between each participant for each of 3 registration  methods: (1) manual registration, (2) BBR initialized with  manual registration (manual+BBR), (3) and BBR initialized  using FLIRT (FLIRT+BBR). Mean CBF was calculated in the  same regions of interest (ROIs) for each registration  method after image alignment. Paired t-tests of CC values  for each registration method were performed to compare  alignment. Mean CBF in each ROI was compared between groups  using t-tests. Differences were considered significant at  p &lt; 0.05 (Bonferroni-corrected). We performed linear  regression to relate FTLD-CDR to mean CBF in patients with  sFTLD-tau and sFTLD-TDP, separately (p &lt; 0.05,  uncorrected).&lt;/p&gt; &lt;p&gt;Results: All registration methods  demonstrated significant hypoperfusion in frontal and  temporal regions in each patient group relative to  controls. All registration methods detected hypoperfusion  in the left insular cortex, middle temporal gyrus, and  temporal pole in sFTLD-TDP relative to sFTLD-tau. FTLD-CDR  had an inverse association with CBF in right temporal and  orbitofrontal ROIs in sFTLD-TDP. Manual+BBR performed  similarly to FLIRT+BBR.&lt;/p&gt; &lt;p&gt;Discussion: ASL is sensitive  to distinct regions of hypoperfusion in patient  participants relative to controls, and in patients with  sFTLD-TDP relative to sFTLD-tau, and decreasing perfusion  is associated with increasing disease severity, at least in  sFTLD-TDP. BBR can register ASL-T1w images adequately for  controls and patients.&lt;/p&gt;},
      url = {http://knowledge.uchicago.edu/record/13285},
}