@article{TEXTUAL,
      recid = {11596},
      author = {Koktzoglou, Ioannis and Ozturk, Onural and Walker, Matthew  and Ankenbrandt, William J. and Ong, Archie L. and Ares,  William J. and Gil, Fulvio R. and Bulwa, Zachary B. and  Edelman, Robert R.},
      title = {Quantitative Time-of-Flight Head Magnetic Resonance  Angiography of Cerebrovascular Disease},
      journal = {Journal of Magnetic Resonance Imaging},
      address = {2024-04-25},
      number = {TEXTUAL},
      abstract = {&lt;p&gt;Background: Standard Cartesian time-of-flight (TOF)  head magnetic resonance angiography (MRA) is routinely used  to evaluate the intracranial arteries, but does not provide  quantitative hemodynamic information that is useful for  patient risk stratification as well as for monitoring  treatment and tracking changes in blood flow over time.  Quantitative TOF (qTOF) MRA represents a new and efficient  method for simultaneous evaluating the intracranial  arteries and quantifying blood flow velocity, but it has  not yet been evaluated in patients with cerebrovascular  disease.&lt;/p&gt; &lt;p&gt;Purpose: To evaluate qTOF for  simultaneously evaluating the intracranial arteries and  quantifying intracranial blood flow velocity in patients  with cerebrovascular disease, without the need for a phase  contrast (PC) scan.&lt;/p&gt; &lt;p&gt;Study Type: Prospective.&lt;/p&gt;  &lt;p&gt;Subjects: Twenty-four patients (18 female, 6 male) with  cerebrovascular disease.&lt;/p&gt; &lt;p&gt;Field Strength/Sequences:  Head MRA at 3 T using gradient-echo 3D qTOF, standard  Cartesian TOF, and PC protocols.&lt;/p&gt; &lt;p&gt;Assessment: Three  independent readers assessed arterial image quality using a  4-point scale (1: non-diagnostic, 4: excellent) and  artifact presence. Total and component flow velocities  obtained with qTOF and PC were measured.&lt;/p&gt; &lt;p&gt;Statistical  Tests: Wilcoxon signed-rank tests, Gwet's AC2, intraclass  correlation coefficients (ICC) for absolute agreement,  Bland–Altman analyses, tests of equal proportions. P values  &lt;0.05 were considered statistically significant.&lt;/p&gt;  &lt;p&gt;Results: Averaged across readers and compared to  standard Cartesian TOF, qTOF significantly improved overall  arterial image quality (3.8 ± 0.2 vs. 3.6 ± 0.5), image  quality at locations of pathology (3.7 ± 0.5 vs.  3.4 ± 0.7), and increased the proportion of evaluations  rated without artifacts (63.9% [46/72] vs. 37.5% [27/72]).  qTOF significantly agreed with PC for total flow velocity  (ICC = 0.71) and component flow velocity (ICC = 0.89).&lt;/p&gt;  &lt;p&gt;Data Conclusion: qTOF angiography of the head matched or  improved upon the image quality of standard Cartesian TOF,  reduced image artifacts, and provided quantitative  hemodynamic data, without the need for a PC scan.&lt;/p&gt;  &lt;p&gt;Evidence Level: 2&lt;/p&gt; &lt;p&gt;Technical Efficacy: Stage  2&lt;/p&gt;},
      url = {http://knowledge.uchicago.edu/record/11596},
}