000011580 001__ 11580
000011580 005__ 20240523051059.0
000011580 024__ $$aUS 11913081 B2
000011580 024__ $$d201716305298
000011580 037__ $$aPATENT
000011580 041__ $$aeng
000011580 245__ $$aProximity-dependent split RNA polymerases as a versatile biosensor platform
000011580 260__ $$c2024-02-27
000011580 260__ $$g2017-06-06
000011580 336__ $$aPatent
000011580 520__ $$aA proximity dependent split T7 RNAP (RNA polymerase) sensor using continuous molecular evolution is described. The versatility of the platform is described by creating robust light and small molecule-responsive genetic sensors. The activity-responsive RNAP platform dramatically simplifies and expands genetic circuit creation, and opens new opportunities in protein engineering, synthetic biology, and bioengineering.


000011580 690__ $$aPhysical Sciences Division
000011580 691__ $$aChemistry
000011580 7011_ $$aDickinson, Bryan C.$$uUniversity of Chicago
000011580 7011_ $$aPu, Jinyue$$uUniversity of Chicago
000011580 7011_ $$aZinkus, Julia$$uUniversity of Chicago
000011580 7121_ $$aUniversity of Chicago
000011580 7131_ $$aUniversity of Chicago
000011580 8564_ $$9a3d772df-b3e5-408a-917e-c245ea470f77$$ePublic$$s2056245$$uhttps://knowledge.uchicago.edu/record/11580/files/US_11913081_B2.pdf
000011580 909CO $$ooai:uchicago.tind.io:11580$$pGLOBAL_SET
000011580 983__ $$aPatent