@article{TEXTUAL,
      recid = {11548},
      author = {Keyport Kik, Samantha and Christopher, Dana and  Glauninger, Hendrik and Wong Hickernell, Caitlin and Bard,  Jared A. M. and Lin, Kyle M. and Squires, Allison H. and  Ford, Michael and Sosnick, Tobin R. and Drummond, D. Allan},
      title = {An adaptive biomolecular condensation response is  conserved across environmentally divergent species},
      journal = {Nature Communications},
      address = {2024-04-11},
      number = {TEXTUAL},
      abstract = {Cells must sense and respond to sudden maladaptive  environmental changes—stresses—to survive and thrive.  Across eukaryotes, stresses such as heat shock trigger  conserved responses: growth arrest, a specific  transcriptional response, and biomolecular condensation of  protein and mRNA into structures known as stress granules  under severe stress. The composition, formation mechanism,  adaptive significance, and even evolutionary conservation  of these condensed structures remain enigmatic. Here we  provide a remarkable view into stress-triggered  condensation, its evolutionary conservation and tuning, and  its integration into other well-studied aspects of the  stress response. Using three morphologically near-identical  budding yeast species adapted to different thermal  environments and diverged by up to 100 million years, we  show that proteome-scale biomolecular condensation is tuned  to species-specific thermal niches, closely tracking  corresponding growth and transcriptional responses. In each  species, poly(A)-binding protein—a core marker of stress  granules—condenses in isolation at species-specific  temperatures, with conserved molecular features and  conformational changes modulating condensation. From the  ecological to the molecular scale, our results reveal  previously unappreciated levels of evolutionary selection  in the eukaryotic stress response, while establishing a  rich, tractable system for further inquiry.},
      url = {http://knowledge.uchicago.edu/record/11548},
}