@article{TEXTUAL,
      recid = {11446},
      author = {Mozumder, Rana and Chung, Sophia and Li, Sihai and  Constantinidis, Christos},
      title = {Contributions of narrow- and broad-spiking prefrontal and  parietal neurons on working memory tasks},
      journal = {Frontiers in Systems Neuroscience},
      address = {2024-03-21},
      number = {TEXTUAL},
      abstract = {Neurons that generate persistent activity in the primate  dorsolateral prefrontal and posterior parietal cortex have  been shown to be predictive of behavior in working memory  tasks, though subtle differences between them have been  observed in how information is represented. The role of  different neuron types in each of these areas has not been  investigated at depth. We thus compared the activity of  neurons classified as narrow-spiking, putative  interneurons, and broad-spiking, putative pyramidal  neurons, recorded from the dorsolateral prefrontal and  posterior parietal cortex of male monkeys, to analyze their  role in the maintenance of working memory. Our results  demonstrate that narrow-spiking neurons are active during a  range of tasks and generate persistent activity during the  delay period over which stimuli need to be maintained in  memory. Furthermore, the activity of narrow-spiking neurons  was predictive of the subject’s recall no less than that of  broad-spiking neurons, which are exclusively projection  neurons in the cortex. Our results show that putative  interneurons play an active role during the maintenance of  working memory and shed light onto the fundamental neural  circuits that determine subjects’ memories and judgments.},
      url = {http://knowledge.uchicago.edu/record/11446},
}