@article{TEXTUAL,
      recid = {11427},
      author = {Chen, Yi-Ju and Wu, David and Gelbart, William and  Knobler, Charles M. and Phillips, Rob and Kegel, Willem K.},
      title = {Two-Stage Dynamics of <i>In Vivo</i>  Bacteriophage Genome Ejection},
      journal = {Physical Review X},
      address = {2018-05-01},
      number = {TEXTUAL},
      abstract = {Biopolymer translocation is a key step in viral infection  processes. The transfer of information-encoding genomes  allows viruses to reprogram the cell fate of their hosts.  Constituting 96% of all known bacterial viruses [A. Fokine  and M. G. Rossmann, Molecular architecture of tailed  double-stranded DNA phages, Bacteriophage 4, e28281  (2014)], the tailed bacteriophages deliver their DNA into  host cells via an "ejection" process, leaving their protein  shells outside of the bacteria; a similar scenario occurs  for mammalian viruses like herpes, where the DNA genome is  ejected into the nucleus of host cells, while the viral  capsid remains bound outside to a nuclear-pore complex. In  light of previous experimental measurements of in vivo  bacteriophage λ ejection, we analyze here the physical  processes that give rise to the observed dynamics. We  propose that, after an initial phase driven by  self-repulsion of DNA in the capsid, the ejection is driven  by anomalous diffusion of phage DNA in the crowded  bacterial cytoplasm. We expect that this two-step mechanism  is general for phages that operate by pressure-driven  ejection, and we discuss predictions of our theory to be  tested in future experiments.},
      url = {http://knowledge.uchicago.edu/record/11427},
}