@article{TEXTUAL,
      recid = {11372},
      author = {McGuinness, Sarah and Sajjadi, Samaneh and Weber,  Christopher R. and Khalili-Araghi, Fatemeh},
      title = {Computational Models of Claudin Assembly in Tight  Junctions and Strand Properties},
      journal = {International Journal of Molecular Sciences},
      address = {2024-03-16},
      number = {TEXTUAL},
      abstract = {Claudins are one of the major components of tight  junctions (TJs) that polymerize within the cell membrane  and form interactions between cells. Some claudins seal the  paracellular space, limiting paracellular flux, while  others form selectively permeable ion channels that control  the paracellular permeability of small ions. Claudin  strands are known to be dynamic and reshape within TJs to  accommodate large-scale movements and rearrangements of  epithelial tissues. Here, we summarize the recent  computational and modeling studies on claudin assembly into  tetrameric ion channels and their polymerization into μm  long strands within the membrane. Computational studies  ranging from all-atom molecular dynamics, coarse-grained  simulations, and hybrid-resolution simulations elucidate  the molecular nature of claudin assembly and function and  provide a framework that describes the lateral flexibility  of claudin strands.},
      url = {http://knowledge.uchicago.edu/record/11372},
}